Reyes easily would have been safe if he had slid into the plate but instead he tried to run through while standing up. Catcher Adrian Nieto had his left leg on top of the plate and that's what Reyes stepped on when he arrived.
Nieto also missed the tag, which prompted home-plate umpire Clint Fagan to not make a call one way or the other. Nieto then walked over to Reyes, made the tag and got the out.
Blue Jays manager John Gibbons argued the call because a clear lane to the plate was not provided as per Rule 7.13. Toronto challenged and the initial ruling was overturned.
Reyes was credited with the run while Jose Bautista reached first base on the fielder's choice.
Toronto got the better end of another challenge in the bottom of the sixth inning when Chicago's Avisail Garcia hit a sharp liner into the right-center field gap. Garcia tried to stretch the hit into a triple but instead was thrown out on a relay throw from Bautista and Reyes.
White Sox manager Robin Ventura challenged the call, but following a brief delay the call on the field was confirmed. It appeared as though third baseman Juan Francisco almost missed the tag, but he got just a piece of Garcia's leg on his slide into the bag.
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.