With the Mariners holding a 3-0 lead and De Aza at first base on a leadoff single, Leone turned and threw while De Aza dove back to the bag.
After the initial safe ruling, Mariners manager Lloyd McClendon challenged the call, and a brief replay review revealed that De Aza didn't reach the bag before being tagged out by first baseman Logan Morrison.
The Mariners went on to win, 4-2.
Adam Lewis is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.