Beckham, the White Sox Opening Day second baseman from 2010-13, appeared in 10 Cactus League games, but last played on March 14. He had been hoping to be ready for the start of the season, but it became clear on Friday that he would indeed start the season on the DL.
Both Beckham and Keppinger will be eligible to return on April 5. For the time being, Marcus Semien will start at second base, while Leury Garcia will fill the utility infielder role.
Paul Casella is a reporter for MLB.com. Follow him on Twitter @paul_casella. This story was not subject to the approval of Major League Baseball or its clubs.