The White Sox are 4-7 against Detroit this season and have lost four straight, including a three-game sweep during the teams' last meeting July 20-22.
Shortly after that series, however, Chicago climbed into first place and has not looked back, giving the White Sox confidence heading into the Motor City.
"We've got to have a good weekend," White Sox second baseman Gordon Beckham said. "We've been on the other side of the coin, where we had to win series against a first-place team to get back in the hunt, and it's not easy. Every game lost to a team that's in the lead can be frustrating, so if we can go in there and just win one, to be honest, it's a victory for us."
With another four meetings with the Tigers in Chicago still on the schedule, Beckham said the team isn't placing too much stock on this weekend.
"Obviously, it's a big series, but we don't want to put too much pressure on ourselves," he said. "We're doing fine. There's no need to make it bigger than it is. We've got seven games left with them, and you want to win at least three or four of those games."