Youkilis reached that milestone with an eighth-inning single off Royals left-hander Tim Collins on Saturday in the White Sox 9-4 loss. The hit, a liner to left, came just before Adam Dunn reached his own milestone with the 400th homer of his career.
Youkilis has started 44 of 47 games since joining the White Sox.
Robert Falkoff is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.