The lineup was adjusted in Youkilis' absence, with Gordon Beckham moving to the leadoff spot and Alexei Ramirez hitting second. Jordan Danks was dropped to the eighth slot, and Olmedo hit ninth.
"I've had stuff. You have aches and pains for a while, but it got to a point where I needed to slow down," Youkilis said of his right knee swelling. "Hopefully, I can come out and play tomorrow. So we'll see tomorrow."
De Aza could return Wednesday, but with Thursday's scheduled off-day, he might get a little extra rest and start the Oakland series fresh on Friday night.
"It is tough [to be out], but I just want to get better," said De Aza, who added that certain movements bother him but he doesn't think it's anything serious. "I'd rather lose two or three days and get healthy and then go back to play instead of trying to play and get worse."
"Even last night, [De Aza] felt better as the game went along," said White Sox manager Robin Ventura. "So he was ready to go in if he had to."