Youkilis said he plans on returning to the lineup for Friday's series opener in Texas against the Rangers. The White Sox have an off-day Thursday.
"It's just a mild sprain. I've played with a lot worse all year," Youkilis said. "Friday I'll be good to go."
Youkilis played the top of the fourth inning before exiting in the bottom of the frame when he was pinch-hit for by Eduardo Escobar.