De Aza launched a 3-2 pitch from Cole De Vries down the right-field line that was originally ruled to be fair by first-base umpire Doug Eddings.
After a brief conference on the field, all the umpires but home-plate umpire Paul Nauert went in to review the call. They came back with a foul-ball ruling, and De Aza took a called third strike to start a scoreless frame.
"Yeah, I know it was foul," said De Aza, who launched his first career grand slam in the sixth. "But I saw the umpire call it fair, so I kept going."
It was the ninth time in White Sox history that they've been involved in the usage of instant replay to review a home run since it was instated in 2008. It's the third time it took place at U.S. Cellular Field.