Crain has been on the disabled list retroactive to April 21 with a strained left oblique muscle, and has one more scheduled outing with the Knights on Sunday.
If Crain performs well there, after striking out one and throwing 14 of his 21 pitches for strikes against Buffalo on Friday, then the White Sox should have a roster decision to make come Monday.
"We are just thinking about today," White Sox manager Robin Ventura said before Saturday's game against the Royals. "But we want to see how he does Sunday before we go into what's going to happen after that."
With Chris Sale back in the starting rotation, the White Sox have Addison Reed, Matt Thornton, Will Ohman, Hector Santiago and Nate Jones seemingly set in the bullpen. That leaves Zach Stewart and Eric Stults working for one spot when Crain returns, with Stewart holding the advantage as the White Sox probably won't go with four southpaws.
Much like Ventura, Stewart isn't worried about roster permutations with a chance for working possible Saturday or Sunday.
"I'm pretty confident in how I've been playing," said Stewart, who had a 2.25 ERA in seven games and eight innings pitched entering Saturday's action. "But I also understand decisions have to be made, and a lot of times, it's business decisions and falls on somebody. It's part of the game."