Of course, Santos was an infielder when he was with Arizona.
"I remember playing exhibition games at shortstop at Chase Field," Santos said. "So, that will be different. It will be exciting to go back and pitch there."
Brian Bruney (2004-05), Adam Dunn (2008) and Edwin Jackson (2010) also played for the D-backs, while numerous White Sox players have Arizona residences. But manager Ozzie Guillen stressed that this weekend is not a vacation for his team.
"That will help you mentally to be ready for the game," Guillen said. "But we're not going there for vacation and visiting family. We're going for business -- tough business -- the Diamondbacks are playing very well. They have a good ballclub, and we have to be aware of that.
"It's always nice to see family and hang around the house. But I don't want them to be in the swimming pool and [having] fun with kids when they have a job to do later."