First baseman Paul Konerko is the first candidate for a breather as he served as the team's designated hitter Thursday night while Adam Dunn got his fifth start of the year at first base.
"[Konerko] is a max out ball player," Guillen said. "He bangs himself up mentally so much about hitting and stuff, and sometimes we have to get him out of there to make sure he relaxes a little bit. [Konerko] goes as hard as he can and we want to help his body."
Right fielder Carlos Quentin will also receive at least one day of rest over the next four games.
Quentin has been battling a sore knee for a few games, and while the injury isn't severe enough to hold him out of the lineup, Guillen does not want him testing it too much on the turf.
"We're going to find a place to get him a break," Guillen said. "Carlos for sure will have a day off here in Toronto."