The White Sox eventually won, 5-4, on A.J. Pierzynski's 10th-inning RBI single off Jose Valverde.
Inge faced White Sox rookie reliever Chris Sale with a runner on and two out in the eighth inning and turned on a 3-1 fastball, sending it soaring down the left-field line. Third-base umpire Tony Randazzo initially ruled it a home run, giving Detroit a 6-4 lead.
Inge said the ball started out so far fair that he initially had hope it would sneak inside the foul pole.
"I was kind of watching it, watching it, started leaking towards first base and then I stopped and came back," Inge said. "And then I saw him pointing, and I was like, OK."
White Sox manager Ozzie Guillen ran out from the dugout to call for a review by the time Inge reached second base. Second-base umpire and crew chief Brian Gorman left the field to review the play.
"At first off the bat, I was like, 'Oh, boy, this is bad. This is not good,'" Sale said. "Then, I saw where it went foul. Pierzynski was back there and was asking if it was fair or foul, and it was way foul. The home-plate umpire didn't make a call, and they circled around and I said I thought it was foul. They went back and reviewed it, and it was big. Thank God it didn't catch fair."
Replay showed the ball clearly foul. Gorman changed the ruling and brought Inge back to the plate, this time with a full count, as much of the crowd of 32,924 booed.
It was the third review the Tigers have encountered this year, and the second at Comerica Park. That, too, was an Inge homer down the left-field line against the White Sox, that one coming against Freddy Garcia. Crew chief Dale Scott overturned that one.
The Tigers have been involved in eight video reviews since Major League Baseball introduced instant replay on Sept. 3, 2008. Seven of those replays involved Detroit hits. The only other Tigers player to have a homer overturned is Dusty Ryan, who had a home run changed to a double on June 19, 2009 against Milwaukee.
Instant replay has been used 114 times, with 43 calls overturned.