The White Sox starter retired Adam Everett for the final out in the 14th inning to secure the 7-5 victory against the Astros and put his club one victory away from its first World Series title in 88 years.
Buehrle, who started Game 2, is the first pitcher to get a start and earn a save in consecutive World Series games.
"This is one of the happiest days of my life," Buehrle said. "To get a save in a World Series is the reason I can't stop smiling."
Buehrle was one of nine pitchers to make an appearance for the White Sox in Game 3. On Sunday, he pitched seven innings and gave up four earned runs on seven hits. He said adrenaline played a big part in his latest appearance.
"I think they told me I could [pitch in Game 3] so I could get out of their hair and quit bugging them," Buehrle joked. "They said they might need me. ... If everybody else in the bullpen is down, I can [pitch in Game 4], but I think it's going to have to be a crazy opportunity like there was today for me to do that."
Even in victory, a diplomatic Buehrle showed respect to his opponents in the opposing clubhouse. He said he and his teammates are "taking it one game at a time."
"The Astros are not going to give up, so we have to come out with the same intensity [in Game 4]," Buehrle said. "We can't go out there thinking like we are up, 3-0. Let's see what happens."
Jesse Sanchez is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.